Propelling your drug discovery program with our streamlined chemistry solutions
Our dynamic chemical science team has a proven track record in medicinal chemistry, chemical development, computational chemistry, and analytical chemistry. Our highly skilled and result-oriented discovery team has contributed to multiple successful programs, maintaining an exceptional degree of client satisfaction. We understand drug discovery and will work with you to design the custom collaboration necessary to advance your project.
Client
Testimonial
“In the last two and half years, with your help, we have set the company on a successful path. You have made critical contributions to creative problem-solving that has helped us achieve these great milestones.”
Experience a collaboration like nowhere else
We offer a multidisciplinary and collaborative environment which enables the exchange of ideas, germination of new concepts, and flawless execution through state-of-the-art chemistry capabilities. Find out how we can advance your project and help you reach your next milestones.
Bioanalytical Solutions
- Quick turnaround for both small-molecule and large-molecule projects
- Bioanalysis of routine in vitro ADME assays and in vivo PK/PD samples from various tissues and biofluids
- In vitro and in vivo metabolite profiling in a variety of media and identification of metabolites using cold material
- Protein characterization and proteomics
- Broad range of more specialized capabilities including custom bioanalytical method development, small biomarker analysis, compound derivatization, and more
Pharmacokinetics (PK) and In Vivo Studies
- Standardized and tailored study designs conducted in rodents and higher species within CCAC accredited facilities
- Single/multiple ascending dose, maximum tolerated dose and acute tolerability studies
- Rat surgical models for drug elimination pathway characterization
- Excretion studies in rodent and non-rodent species
- Formulation development for pre-clinical in vivo studies
In Vitro ADME
- Variety of in vitro assays suitable for both early-stage drug discovery and advanced compound profiling
- Cell permeability assays
- Metabolic stability assessments in microsomes, cytosol, hepatocytes, plasma, blood, and other matrices
- Protein binding measurement by equilibrium dialysis
- Solubility studies at various pHs, including biorelevant buffers
- Specialized procedures such as nuclear receptor assays, transporter studies, and cell viability assays are also available
In Vivo Pharmacology
- Xenograft, allogeneic, orthotopic cancer models
- Inflammation and sepsis models
- Maintenance of mouse colonies
- IVIS in vivo imaging
- Custom optimized formulations
- CCAC accredited facilities
Cellular Pharmacology
- Mechanism of action (M.O.A.) and target validation studies
- Homogeneous assays for drug screening
- Regulation of gene expression, proliferation and cytotoxicity assays
- Gene expression assays
- Cytokine array assays (Luminex®)
- Drug combination studies
- Post-translational modifications
- Primary cells, iPSC and PBMC culture, differentiation and activation
Biochemistry & Biophysics
- Compound Screening, Hit-to-Lead and SAR
- Protein expression and purification
- Customized biochemical assays
- Biophysics
State-of-the art instrumentation
- Access to more than 40,000 chemicals in inventory
- Chemistry database
- Automated purification systems
- 400 and 500 MHz NMR spectrometers
- Open access UPLC-MS systems
- Open access Prep-MS HPLC systems
- Microwave synthesizers
- Parr shakers
- Ozone generators
- Photoreactors (Penn PhD)
- Electrochemistry kits (IKA)
- Hydrogenation bombs
- Walk-in fume hoods
- Reactors (up to 30 L)
- Jacketed filter dryer (5 L capacity)
- Photochemical reactors (up to 2 L)
- Electrochemical reactors (up to 4 L)
- Large-scale rotary evaporator (20 L capacity)
- Flow chemistry setup
- HT-12 GeneVac evaporation system
- Peptide synthesizer
- Karl-Fischer titrator
- Polarimeter
- Multi-experiment automated workstation (Tecan)
- UPLC-UV-MS systems
- HPLC-UV systems
- HPLC-UV-MS systems
- LC-UV-ELSD-MS systems
- UPC2-UV-MS system
- UPC2-UV system
- SFC-UV-MS Prep 15 systems
- Auto purification semi-prep systems
Our Departments
