Go beyond just data: innovate, collaborate, solve your programs hurdles
Paraza’s vision is to provide drug discovery expertise that is—intellectually and experimentally— an extension of client-partner teams. Our strength is science and the people who do it. The key to our success is our team of exceptionally well-trained and experienced drug discovery professionals that contribute to project goals in a timely manner. Paraza thrives on free and open communication with client-partners and is passionate about contributing to the discovery of truly innovative new medicines.
Scientific areas of expertise within Paraza
Paraza’s core capabilities and expertise
Candidate
Selection
- Establish PK/PD models
- Cross-species PK
- Scale-up, multi-gram to kilogram
- Determine max tolerated dose
Target ID &
Validation
- Validation using tool compounds or gene KO/KD
- Protein generation (E. coli and mammalian cells)
- Assay development
In-House Proprietary Library Screen
- A novel, home-grown chemical library
- Designed and developed by Paraza scientists
- Truly unique 3D architecture and vectoring capacity
- Favourable physiochemical property space
Lead
Optimization
- Improve potency & PK
- Multi-parameter optimization
- Mitigate off-target activity
- In vivo efficacy
Lead
Identification
- Scaffold/series evaluation
- Minimum pharmacophore
- Basic physical-chemical property analysis (ADME)
- Viable SAR
Hit
Identification
- HTS, fragment and virtual screening
- Hit confirmation, counter-screening and triaging
- (Re)-Synthesis
Client
Testimonial
"I don’t think I can adequately express how grateful I am to have worked with you and your team over the past 1+ year… Having you and the team to talk with, bounce ideas off, and learn from has made all the difference… It is amazing how much data was generated in such a short period of time."
Our Resourcing Models
Full Time Equivalent (FTE)
- Our FTE rates are built to be inclusive
- Chemistry FTE includes most chemicals and routine analytical support (including chiral separations)
- For Biology FTEs, project-specific materials are charged as a pass-through cost
- No charges for project management oversight on projects
Fee For Service (FFS)
- DMPK is based on the FFS model
- This model can be the favored mode for some applications in Chemistry and Biology such as:
- Specific compound synthesis or reaction/route optimization
- Pharmacology studies
- Well-defined biochemical or cell biology studies
- High-throughput screening
