Comprehensive bioanalytical services for drug discovery and development
Our dedicated and experienced team offers bioanalytical services on both a standalone basis and as part of a fully integrated program. We provide seamless support for various drug discovery or development programs by delivering reliable bioanalysis data within a quick turnaround time for either small or large molecules using our state-of-the-art equipment.
Client
Testimonial
"You should all take a lot of pride in what you have built – a very impressive drug hunting machine!”
Bioanalysis of routine in vitro ADME assays with well-established bioanalytical procedures
- Generic HPLC/UPLC methods with internal standards cocktail
- Well-established procedures for rapid optimization of mass spectrometric parameters
- High throughput data processing and reporting for all routine in vitro assays
Bioanalysis of in vivo PK/PD samples from various tissues and biofluids
- Robust LC-MS/MS quantification method development based on understanding of structural/physicochemical properties of test compounds
- Method qualification includes accuracy, precision, linearity, sensitivity, selectivity, blank cleanliness and carryover evaluation
- Sensitive LC-MS/MS methods allow the analysis of limited sample volume from microsampling or certain biofluids.
Metabolite profiling
- Metabolite profiling and identification can be studied in in vitro microsomal, hepatocyte and plasma incubations, as well as in in vivo plasma or tissue samples
- Metabolite profiling can be compared between different species (mouse, rat, dog, monkey, human, etc.)
- A high-resolution Orbitrap mass spectrometer and corresponding metabolite analysis software will be used
Proteomics studies and protein characterizations
- Targeted protein quantification including therapeutic biologics and biomarkers
- Protein characterization including protein MW determination and identification of post-translational modifications
- Proteomics studies such as isobaric tag-based quantitative proteomics analysis for drug target identification, or proteome-wide off-target protein mapping of a covalent inhibitor using the SILAC-ABPP method
- HDX approach for observing conformational states of target protein in the presence of various ligands
Special Capabilities
- Fit-for-purpose bioanalytical method development
- Small biomarker analysis, such as fatty acids, amino acids, nucleotides, glycan, and glycosphingolipids
- Compound derivatization for sensitive LC-MS/MS detection
- PEGylated compound analysis
- Isotope purity and residual solvent analysis
Instrumentation
- Triple quadrupole LC‐MS/MS systems
- High‐resolution Q‐Exactive LC‐MS/MS systems
- UHPLC-DAD system
- Automated liquid handler (Beckman) for sample preparation
- OMNI Bead Ruptor Elite tissue homogenizer
