A portfolio of in vitro assays to meet your needs
We offer a wide variety of in vitro assays covering early-stage drug discovery and more advanced compound profiling. Most of our assays are offered in either screening mode (suited for medium-high throughput) or profiling mode, in order to best fit your needs.
Client
Testimonial
"IYou have assembled a truly remarkable team who not only knows how to present science but also knows the science of drug discovery in depth. I have already recommended Paraza to a company that I serve as a board member…"
Metabolism
- Metabolic stability assessment
- Microsomes (from liver, intestines, lungs)
- Hepatocytes
- Cytosol and S9 fractions
- Plasma
- Whole blood
- Other active matrices
- Metabolite profiling
- CYP450 Reaction Phenotyping
Drug-Drug Interaction
- CYP inhibition (seven FDA-recommended isoforms available)
- Reversible inhibition
- Time Dependent Inhibition (TDI) in IC50 shift mode
- CYP induction using cryopreserved hepatocytes from qualified donors
- Nuclear receptor assays (PXR, others available on demand)
- hERG (via our local collaborator)
Permeability
- Cell permeability assays
- Caco-2 cells
- MDCK
- MDCK-mdr1
- Transporters (P-gp, mrp2, BCRP)
- Substrate
- Inhibition
Protein binding and plasma partitioning
- Protein binding measurement by equilibrium dialysis (1 mL or HTD mode)
- Plasma
- LM
- Tissue homogenates
- Whole blood and red blood cell: plasma partitioning
Physicochemical Screening
- Kinetic solubility at various pHs, including biorelevant buffers
- Thermodynamic solubility under various conditions, including biorelevant buffers
- LogD7.4
- Chemical Stability
