DMPK

BIOANALYTICS

Fit-for- purpose non-GLP method development and sample analysis for all relevant in vitro and in vivo matrices. All bioanalyses are performed in-house, using state-of-the-art equipment.

Analysis in DMPK

• Bioanalysis with well-established procedures for all routine in vitro ADME studies, such as plasma binding, permeability assays, metabolic stability, solubility and CYP inhibition.
• Bioanalysis of in vivo pharmacokinetic (PK) samples from different matrices, such as plasma, feces, urine, CSF and various tissues.
• Bioanalysis of small, volatile or hydrophilic compounds using LC-MS/MS or GC-MS.
• Metabolite identification using high resolution mass spectrometry.

Analysis in Chemistry

• Isotope purity determination using high resolution mass spectrometry.
• Residual solvent determination in new chemical entities using Headspace-GC-FID.

Analysis in Protein Science

• Targeted protein quantification including therapeutic biologics and biomarkers.
• Protein characterization including protein MW determination and identification of post-translational modifications.
• Proteomics studies such as proteome-wide off-target protein mapping of a covalent inhibitor using the SILAC-ABPP method.