Chemical Sciences

CHEMICAL DEVELOPMENT

Our chemical development group is composed of highly skilled and creative synthetic organic chemists with a proven track record of developing, improving, and enabling synthetic methodologies to challenging molecules. We provide high quality custom/contract or FTE chemistry services at competitive rates to match our customers’ needs including participating in collaborative R&D projects. We use state of the art synthetic chemistry methodologies and innovative design of synthetic routes to ensure optimal productivity and efficiency to meet project timelines.

Key Skills & Expertise

• Production capacity from milligram to kilogram
• Highly independent problem solving teams
• Team based approach for rapid delivery of project goals
• Design and optimization of synthetic strategies and reactions
• Synthesis of intermediates and building blocks to support medicinal chemistry
• Selective functionalization/modification of natural products and complex late-stage
• Validation of synthetic routes
• Delivery of clear, detailed project reports with full compound characterization for technology transfer
• Optimization of compound purification and isolation
• Isolation and characterization of reaction side products
• Gram-scale stereoselective total synthesis of complex natural products and their analogs (see, for example: Ding, H.; DeRoy, P.; Perreault, C.; Larivee, A.; Siddiqui, A.; Caldwell, C. G.; Harran, S.; Harran, P. G. Angew. Chem. Int. Ed. 2015, 54, 4818)
• State of the art equipment for large scale chemical synthesis
• Preparation of stable labeled isotope standards for bioanalysis
• Cost and time efficient synthetic routes
• Non-GLP process development in prevision of GLP campaign

Equipment

• 5 L to 20 L reactors
• Up to 2 L photochemical reactor
• 0.05 L to 4 L electrochemical reactors
• 20 L Buchi evaporators
• Flow chemistry setup
• Walk-in fume hoods
• And more!