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Principal Scientist/Associate Director, Computer-Aided Drug Design

Paraza Pharma, Inc.

Paraza Pharma, Inc. is a fast-growing pharmaceutical research company offering a dynamic and collaborative work environment where scientific excellence, innovation and creativity are at the forefront. Here, diversity, new points of view and a creative spirit are valued and considered as real assets. We provide our employees with ongoing support, training and development opportunities to expand their horizons while contributing to our shared passion for Drug Discovery.

Job Description – Role of Principal Scientist/Associate Director, CADD

We are seeking a talented Principal Scientist/Associate Director, CADD (Computer-Aided Drug Design) to join our team. The candidate must have expertise and experience in structure-based, ligand-based drug design, and ADMET modeling. He/She will support the medicinal chemistry group by implementing appropriate computational solutions to small-molecule drug design problems.

Key components in this role are to address key issues to guide drug design and to effectively communicate modeling information to project teams.

Key Responsibilities

  • Apply a variety of computational chemistry methods to improve potency, selectivity, and ADMET properties
  • Develop hypotheses to understand small molecule binding and SAR by interpreting data using modeling and data-mining techniques
  • Effectively interpret and present modeling solutions to project teams
  • Closely collaborate with medicinal chemists
  • Provide guidance, support, and training to CADD group members
  • Develop methods/strategies to enhance our drug design capabilities


  • Ph.D. in computational chemistry or related field
  • 8+ years of small molecule drug discovery experience within a pharmaceutical or biotech environment
  • Proven track record in the application of computational chemistry approaches to help advance drug discovery projects
  • People management experience of a small team
  • Advanced knowledge of computational chemistry principles and knowledge of how to apply these techniques to drug discovery projects
  • Expert level experience in structure-based and ligand-based drug design approaches, including homology modeling, docking (induced-fit docking and covalent docking), virtual screening (docking-based and ligand-based), pharmacophore modeling, molecular dynamics, QM calculation, scaffold hopping, enumeration
  • Experience or knowledge in applying machine learning to drug discovery (e.g. QSAR, ADMET modeling) is required
  • Experience in one of the molecular modeling packages, such as MOE, Schrodinger Suites, ICM or OpenEye
  • Knowledge of scripting languages (e.g. Python)
  • Creative and strong problem-solving capabilities
  • An understanding of medicinal chemistry in order to effectively communicate with chemists
  • Excellent oral and written communication skills and be able to clearly present their research to a broad audience
  • Ability to work on multiple projects in parallel within a fast-paced environment

At Paraza Pharma Inc., you will enjoy an attractive compensation package, a safe and healthy work environment and a full range of health and lifestyle benefits.

Paraza Pharma Inc., will work with the selected candidate to obtain the required work authorization to legally work in Canada.

Alternately, it will be possible to work remotely.

Please note that foreign researchers may be eligible to a 5-year degressive provincial income tax exemption.

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