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In Vitro Pharmacology Associate

Paraza Pharma, Inc.

Paraza Pharma, Inc. is a fast-growing pharmaceutical research company offering a dynamic and collaborative work environment where scientific excellence, innovation and creativity are at the forefront. Here, diversity, new points of view and a creative spirit are valued and considered as real assets. We provide our employees with ongoing support, training and development opportunities to expand their horizons while contributing to our shared passion for Drug Discovery.

Job Description In Vitro Pharmacology Associate  

The Biological Sciences Department at Paraza has an opportunity for an associate cell biologist who will generate tools and develop assays needed to drive drug discovery projects.  You should also be able to implement novel experiments to answer key mechanism of action or translational biology questions. At Paraza we work on a diverse project portfolio covering many disease areas; therefore, the ideal candidate will have a wide skill set and an ability to successfully transition between projects and research areas.

Depending on the project, key activities may include:

  • Development, validation and execution of cellular assays for compound evaluation in 96- and 384-well plates
    • Proliferation, cytotoxicity, and reporter
    • Pathway engagement or protein degradation, such as ELISAs and AlphaLISAs
    • GPCR and ion channel binding and functional assays
  • Characterization of small molecule pharmacology in cells, using classic and state-of-the-art cell biology techniques, for example: IP-western blot, qRT-PCR, flow cytometry, cytokine bead arrays, fluorescence-based imaging, etc.
  • Extraction of total protein, DNA or RNA from both cellular and tissue samples
  • Manipulation of established cell lines including generation of stable cell lines by overexpression, shRNA silencing or CRISPR knockout.
  • Interpretation of experimental data and proposal of follow-up experiments
  • Regular communication of results and ideas with supervisor, colleagues and clients

Minimum Qualifications:

  • M.Sc. in biology or closely related discipline. Experience in Biotech/Pharma strongly preferred. Alternatively, a B.Sc. in biology with at least three years of Biotech/Pharma work experience.
  • Experience in setting up, performing, and troubleshooting 96/384-well plate assays
  • Recognized abilities in mammalian cell culture and performance of cell biology experiments
  • Ability to handle multiple projects in a fast-paced environment
  • Motivation to build on your current knowledge by developing expertise in new techniques and new areas of disease biology
  • Ability to communicate effectively in English: oral, written, presentations

Preferred Qualifications:

  • Demonstrated knowledge of small molecule drug discovery, including necessary laboratory activities to support advancement of lead optimization projects
  • Experience with liquid handling work stations and other automation
  • Working knowledge of French

To apply for this position, please send us your CV and a cover letter describing why you are an appropriate candidate for this position. Your CV should include information on your university and post-graduate academic training (e.g. degree, University, timeframe and research advisor), a list of relevant post-university employment, and a complete list of your publications.

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