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Biochemistry Scientist

Job Type:  Permanent Full Time
Region:  Technoparc Montréal (Ville St-Laurent)

Paraza Pharma, Inc.

Paraza Pharma, Inc. is a fast-growing pharmaceutical research company offering a dynamic and collaborative work environment where scientific excellence, innovation and creativity are at the forefront. Here, diversity, new points of view and a creative spirit are valued and considered as real assets. We provide our employees with ongoing support, training and development opportunities to expand their horizons while contributing to our shared passion for Drug Discovery.

Biochemistry Scientist Job Description 

The biology department at Paraza has an opportunity for a biochemist who will generate purified proteins and develop biochemical assays needed to drive drug discovery projects.  You should also be able to perform enzymological and biophysical experiments to determine the mechanism of action of small molecule inhibitors. At Paraza we work on a diverse project portfolio covering many disease areas; therefore, the ideal candidate will have a wide skill set and an ability to successfully transition between projects and research areas.

Key activities may include: 

  • Expression of proteins from bacteria, insect cells or mammalian cells and purification using multiple types of chromatography
  • Use of purified proteins to develop and perform 96- and 384-well plate biochemical assays for small molecule inhibitors
  • Enzymological characterization of small molecule mechanism of action, using spectroscopy of various types, and radiometric methods
  • Biophysical characterization molecular interactions using surface plasmon resonance (SPR), differential scanning fluorimetry (DSF), isothermal titration calorimetry (ITC), microscale thermophoresis  (MST) and other techniques
  • Quantitative data analysis using appropriate mathematical models and data fitting procedures
  • Interpretation of analyzed data and proposal of follow-up experiments
  • Regular communication of results and ideas to company management and customers

Minimum Qualifications 

  • Ph.D. in biochemistry or closely related discipline. Postdoctoral experience preferred. Alternatively a M.Sc. in biology with at least seven years of work experience.
  • Recognized abilities in the use of purified proteins to address structural or mechanistic questions using multiple biochemical and/or biophysical techniques
  • High level of self-confidence and a demonstrated ability to propose new directions for research or novel solutions to biology/drug discovery problems
  • Motivation to build on your current knowledge by developing expertise in new techniques and new disease areas
  • Ability to communicate effectively in English: oral, written, presentations

Preferred Qualifications 

  • Experience in recombinant protein expression and purification
  • Demonstrated knowledge of small molecule drug discovery, including necessary laboratory activities to support advancement of lead optimization projects
  • Experience in establishing the mechanism of action of small molecule drugs
  • Experience in setting up, performing, and troubleshooting 96/384-well plate assays
  • Experience with liquid handling work stations and other automation.
  • Experience in mammalian cell culture and performance of cell biology experiments
  • Working knowledge of French

To apply for this position, please send us your CV and a cover letter describing why you are an appropriate candidate for this position. Your CV should include information on your university and post-graduate academic training (e.g. degree, University, time frame and research advisor), a list of relevant post-university employment, and a complete list of your publications (with full authorship list, article title, and journal reference, not just web links).

 

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