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Scientist in drug discovery and cell biology

Scientist opportunity in drug discovery and cell biology

Paraza Pharma Inc., located in Montreal, Canada has built a global reputation for providing high quality fully integrated drug discovery services. Paraza is a rapidly growing research organization which offers a dynamic and collaborative work environment where scientific excellence, innovation and creativity are at the forefront. The company is staffed by talented chemists and biologists and currently has approximately 140 employees.


Cell biology Scientist job description

The biology department at Paraza has an opportunity for a cell biologist who will generate tools and develop assays needed to drive drug discovery projects.  You should also be able to implement novel experiments to answer key mechanism of action or translational biology questions. Experience in designing and performing in vivo studies based on in vitro results will be considered a valuable asset. At Paraza we work on a diverse project portfolio covering many disease areas; therefore, the ideal candidate will have a wide skill set and an ability to successfully transition between projects and research areas.


Key activities may include:

  • Characterization of small molecule pharmacology in cells, using classic and state-of-the-art cell biology techniques, for example: IP-western blot, qRT-PCR, flow cytometry, ELISA, cytokine bead array, fluorescent and label-free imaging, etc.
  • Manipulation of established cell lines including generation of stable cell lines by overexpression, shRNA silencing or CRISPR knockout.
  • Culture and manipulation of primary cells
  • Implementation of in vivo models, g. for cancer, inflammation, metabolic or infectious diseases
  • Extraction of total protein, DNA or RNA from tissue samples
  • Development and validation of cellular assays for compound evaluation in 96- and 384-well plates
  • Interpretation of experimental data and proposal of follow-up experiments
  • Regular communication of results and ideas to company management and customers


Minimum Qualifications:

  • PhD. in biology or closely related discipline. Postdoctoral experience preferred. Alternatively an M.Sc. in biology with at least seven years of work experience.
  • Recognized abilities in mammalian cell culture and performance of cell biology experiments
  • High level of self-confidence and a demonstrated ability to propose new directions for research or novel solutions to biology/drug discovery problems
  • Motivation to build on your current knowledge by developing expertise in new techniques and new areas of disease biology
  • Ability to communicate effectively in English: oral, written, presentations


Preferred Qualifications:

  • Experience in the design and performance of in vivo studies
  • Demonstrated knowledge of small molecule drug discovery, including necessary laboratory activities to support advancement of lead optimization projects
  • Experience in establishing the mechanism of action of small molecule drugs
  • Experience in setting up, performing, and troubleshooting 96/384-well plate assays
  • Experience with liquid handling work stations and other automation.
  • Working knowledge of French


To apply for this position, please send us your CV and a cover letter describing why you are an appropriate candidate for this position. Your CV should include information on your university and post-graduate academic training (e.g. degree,University, timeframe and research advisor), a list of relevant post-university employment, and a complete list of your publications (with full authorship list, article title, and journal reference, not just web links).

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